Gene information
Official symbol IL6ST
Official full name interleukin 6 signal transducer
Gene type protein-coding gene
Chromosome5q11.2
Alias symbolGP130; CD130; sGP130
Gene familyCD molecules; Fibronectin type III domain containing; Interleukin receptors
Resources
Entrez Gene 3572
HGNC HGNC:6021
Ensembl ENSG00000134352
Vega OTTHUMG00000097043
UCSC uc003jqq.4
GO terms: 109 records
GO Description Category LogP Number of genes Detail
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0002065 columnar/cuboidal epithelial cell differentiation GO Biological Processes -7.52899002 17 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0002675 positive regulation of acute inflammatory response GO Biological Processes -10.8573789 13 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0004896 cytokine receptor activity GO Molecular Functions -9.30297759 21 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005138 interleukin-6 receptor binding GO Molecular Functions -7.06549339 4 More
GO:0005975 carbohydrate metabolic process GO Biological Processes -4.30473825 38 More
GO:0005976 polysaccharide metabolic process GO Biological Processes -1.89397709 4 More
GO:0005977 glycogen metabolic process GO Biological Processes -2.60109953 4 More
GO:0006073 cellular glucan metabolic process GO Biological Processes -2.56813882 4 More
GO:0006091 generation of precursor metabolites and energy GO Biological Processes -5.87282466 19 More
GO:0006112 energy reserve metabolic process GO Biological Processes -4.0688237 6 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0008593 regulation of Notch signaling pathway GO Biological Processes -4.89883771 15 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010543 regulation of platelet activation GO Biological Processes -12.2843439 12 More
GO:0010574 regulation of vascular endothelial growth factor production GO Biological Processes -24.2705452 18 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0010611 regulation of cardiac muscle hypertrophy GO Biological Processes -13.5611908 22 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014015 positive regulation of gliogenesis GO Biological Processes -11.0528361 19 More
GO:0014743 regulation of muscle hypertrophy GO Biological Processes -14.1608908 23 More
GO:0015980 energy derivation by oxidation of organic compounds GO Biological Processes -4.48580735 13 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0034110 regulation of homotypic cell-cell adhesion GO Biological Processes -6.42713539 7 More
GO:0034112 positive regulation of homotypic cell-cell adhesion GO Biological Processes -5.83914312 5 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043502 regulation of muscle adaptation GO Biological Processes -16.8828965 29 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0044042 glucan metabolic process GO Biological Processes -2.56813882 4 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044262 cellular carbohydrate metabolic process GO Biological Processes -2.06537786 14 More
GO:0044264 cellular polysaccharide metabolic process GO Biological Processes -1.97395185 4 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045667 regulation of osteoblast differentiation GO Biological Processes -10.7517956 27 More
GO:0045669 positive regulation of osteoblast differentiation GO Biological Processes -8.83631876 18 More
GO:0045685 regulation of glial cell differentiation GO Biological Processes -7.97684638 17 More
GO:0045687 positive regulation of glial cell differentiation GO Biological Processes -7.00526019 12 More
GO:0045747 positive regulation of Notch signaling pathway GO Biological Processes -4.59833472 10 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0048565 digestive tract development GO Biological Processes -11.5666667 27 More
GO:0048710 regulation of astrocyte differentiation GO Biological Processes -5.46031079 9 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0055123 digestive system development GO Biological Processes -12.1524002 29 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060575 intestinal epithelial cell differentiation GO Biological Processes -5.74582458 8 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0070741 response to interleukin-6 GO Biological Processes -9.27147512 9 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071354 cellular response to interleukin-6 GO Biological Processes -8.31494447 8 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0090330 regulation of platelet aggregation GO Biological Processes -3.43776968 4 More
GO:0097110 scaffold protein binding GO Molecular Functions -3.84008123 6 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1901731 positive regulation of platelet aggregation GO Biological Processes -3.59511628 3 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04550 Signaling pathways regulating pluripotency of stem cells KEGG Pathway -2.54669304 7 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05203 Viral carcinogenesis KEGG Pathway -1.94955729 7 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
bazedoxifene DTC 24456369 view
raloxifene DTC 24456369 view
satralizumab antagonist ChemblInteractions view
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
IL6ST transcriptomics acute myocardial infarction[diagnosis] acute myocardial infarction Anderson DR et al. Cytokine. 2013
NM_002184.4:c.442G>C genomics myocardial infarction[diagnosis] myocardial infarction Benrick A et al. Regul Pept. 2008
interleukin-6 receptor subunit beta proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kanda T et al. Cardiology. 2000
interleukin-6 receptor subunit beta proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Anderson DR et al. Cytokine. 2013
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